Updated:LONDON (AP) (AP)
ong> - Colin Kaepernick led the way with his arm and with his feet, throwing for one touchdown and running for two more Sunday to lead the San Francisco 49ers over the Jacksonville Jaguars 42-10 at Wembley Stadium.
Kaepernick ended up with 164 yards passing and 54 yards rushing to improve the team to 6-2. Frank Gore also ran for two scores.
The Jaguars (0-8) were the "home" team at London's iconic soccer venue, playing in the British capital for the first of their four-year run of regular-season NFL games in London.
They had plenty of fan support, too, with many of the 83,559 spectators waving their giveaway Jaguars flags throughout the evening.
None of that affected what was happening on the field, and on the field it wasn't pretty for the Jags.
Kaepernick made his first big play on San Francisco's first possession, quickly throwing to fullback Bruce Miller on the right sideline for a 43-yard gain.
A few plays later, Kaepernick scrambled for 4 1/2 yards on a 3rd and 5, setting up Gore for a short gain and a first down.
After an incomplete pass, Gore ran 19 yards for the first touchdown.
Kaepernick took over the scoring after that, running 13 yards and diving into the corner for the second touchdown late in the first quarter, then passing to Vernon Davis in the corner of the end zone for another, and finally holding it and scrambling for 7 yards and a touchdown.
And all in the first half.
Besides a 38-yard field goal by Josh Scobee in the waning seconds of the half to make it 28-3, Jacksonville had little to be happy about. But the 49ers fumbled in their own territory late in the third quarter, giving the Jaguars their best chance to score. They took it as Chad Henne tossed a 29-yard touchdown pass to Mike Brown to make it 28-10 with 3:00 to go.
But the Niners bounced right back, first with Kyle Williams returning the kick 47 yards before getting pushed out of bounds. Kendall Hunter ran 41 yards on the next play, bringing the ball to the Jacksonville 13.
Gore then ran for 9 yards, 2 yards and the final 2 on three straight plays for the touchdown.
San Francisco linebacker Dan Skuta scored the final points, recovering a fumble and running it back 45 yards for a touchdown after Marcedes Lewis let the ball loose following a 6-yard completion from Henne.
Sunday's encounter was the eighth regular-season NFL game at Wembley, the home of England's national soccer team, and the second this year. The Minnesota Vikings beat the Pittsburgh Steelers 34-27 last month.
Next year, there will be three games in London. The Jaguars will face the Dallas Cowboys in their second game of the four-game stretch, while the Detroit Lions will play the Atlanta Falcons and the Miami Dolphins will take on the Oakland Raiders.
NOTES: R&B artist Ne-Yo sang "The Star-Spangled Banner" and Laura Wright sang "God Save the Queen." ... Former San Francisco quarterback Joe Montana and receiver Dwight Clark were the honorary captains for the 49ers. ... It was San Francisco's second game at Wembley. The Niners beat the Denver Broncos 24-16 in 2010.