Manuel became the first quarterback selected on Thursday, and filled a big need for a Bills team that's rebuilding under new coach Doug Marrone. Manuel was the most accurate passer at Florida State, where he completed nearly 67 percent of his passes.
Listed at 6-foot-4 and 237 pounds, Manuel has a strong arm, is mobile and went 25-6 in four years with the Seminoles.
Before making their first selection at eighth overall, the Bills swung a trade with St. Louis. Aside from swapping first-round picks, Buffalo also acquired the Rams' second- and seventh-round selections (46th and 222nd overall). The teams also exchanged third-round picks.