Reggie Johnson added 15 points for Miami (20-3, 11-0 ACC), which became the first team to start the league season 11-0 in a dozen years.
Florida State (13-11, 5-6 Atlantic Coast Conference) tied the game at 51 midway through the second half on Okaro White's tip-in, but never got the lead. Then Larkin took over.
The Hurricanes overcame an early 13-2 deficit to lead 38-30 at halftime. White led the Seminoles with 15 points before fouling out with 2:04 left.