Health

COPD: An antibiotic a day keeps flare-ups away?

WHAT IS COPD? Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases, which make breathing extremely difficult. There are two main forms of COPD: Chronic bronchitis, which consists of a long-term cough with mucus and the second, is emphysema, which involves destruction of the lungs over time. People with COPD usually have a combination of both conditions. At least 13 million people, in the United States alone, suffer from a form of COPD. SOURCE: (www.ncbi.nlm.nih.gov/pubmedhealth)

CAUSES: Smoking is the leading cause of COPD. The more a person smokes, the more likelihood that person will develop a form of COPD. In rare cases, nonsmokers who lack a protein called alpha-1 antitrypsin can develop emphysema.

OTHER RISKS FACTORS: Others factors that can contribute to COPD are: exposure to certain gases or fumes in the workplace; breathing in heavy amounts of secondhand smoke and pollution; and lighting a fire without having proper ventilation.

SYMPTOMS: Signs of COPD can consist of having a dry or wet cough; fatigue, shortness of breath (dyspnea) that gets worse with mild activity; having trouble catching one's breath; and wheezing. SOURCE: (www.ncbi.nlm.nih.gov/pubmedhealth)

BREAKTHROUGH STUDY: There is no cure for COPD, but a study is published in The New England Journal of Medicine showed a common antibiotic, called azithromycin, reduced the number of flare-ups in patients with COPD.

In the study, 570 patients with COPD took 250 milligrams of azithromycin daily for a year, 572 others to a placebo pill that looked the same. Typically, a patient with COPD who has a flare-up is given a course of antibiotics, but not long-term. The researchers decided to look at the long-term treatment because similar regimens have shown promise in other lung diseases, including cystic fibrosis.

Compared to placebo, the antibiotic reduced flare-ups by about 20%. At the one-year mark, those in the placebo group had on average 1.83 flare-ups, but those in the antibiotic group had 1.48.

PREVENTION: The best way to prevent COPD is by not smoking or by quitting smoking.

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